©2019 by David Robert Grimes. 

RESEARCH INTERESTS AND PAPERS

My research interests are quite broad. My main research focus concerns the mathematical modelling and mechanistic understanding of hypoxia (low oxygen) in cancer, which has severe implications for treatment response and tumour evolution. I am also interest in radiation interactions, and my PhD research was on ultraviolet dose models. Aside from that, I have authored papers on the physics of electric guitar playing and why huge conspiracies are prone to collapse rapidly. My University of Oxford research page can be found here, and my full google scholar profile here. A selection of my papers with download links are given below - feel free to contact me for any data / queries. Where papers are open access, I have linked directly to Journal site - for non OA papers, I have included links to the Author proof.  

2018

  • "Access to HPV vaccination for boys in the United Kingdom" - G Prue, DR Grimes,  P Baker,M Lawler,  Medicine Access, Available here

  • "Oxygen diffusion in ellipsoidal tumour spheroids" - DR Grimes,   FJ Currell, Royal Society Open Science. Available here

  • "Hypoxia increases the tempo of evolution in the peri-necrotic niche in glioblastoma" - DR Grimes, RJ Macauley,  FJ Currell, JG Scott, D Basanta- BioRxiv Preprint Available here

  • "Observation of dose-rate dependence in a Fricke dosimeter irradiated at low dose rates with monoenergetic X-rays" - M O’Leary, D Boscolo, N Breslin, JMC Brown, IP Dolbnya, C Emerson, C Figueira, OJL Fox, DR Grimes, V Ivosev, AK Kleppe, A McCulloch, I Pape, C Polin, N Wardlow, FJ Currell- Nature Scientific Reports Available here

  • "Distinguishing polemic from commentary in science: Some guidelines illustrated with the case of Sage and Burgio, 2017" - DR Grimes, DV Bishop,  Child Development- Expanded PeerJ Preprint Available here

  • Modeling Science Trustworthiness Under Publish Or Perish Pressure" - DR Grimes, CT Bauch and JPA Ioannidis,  Royal Society Open Science,  Available here

2017

  • "Dose quantification in UV phototherapy" - DR Grimes,  Ultraviolet Light in Human Health, Diseases and Environment (Book Chapter), pp 349-360, Springer Publishing. Chapter available upon request. 

  • "An approximate analytical solution of the Bethe equation for charged particles in the radiotherapeutic energy range" - DR Grimes, DR Warren and M Partridge, Nature Scientific Reports - Available here (Open access) 

  • "Hypoxia imaging and radiotherapy: bridging the resolution gap" - DR Grimes, DR Warren and S Warren,  British Journal of Radiology - Available here (Open access)

2016

  • "Oxygen partial pressure is a rate-limiting parameter for cell proliferation in 3D spheroids grown in Physioxic culture condition" - A Gomes, L Guillaume, DR Grimes, J Fehrenbach, V Lobjois, B Ducommun, PLoS One - Available here (Open access)

  • "Simulation of parabolic reflectors for ultraviolet phototherapy" - DR Grimes, Physics in Medicine and Biology - Available here (ResearchGate author proof)  

  • "The role of oxygen in avascular tumor growth" - DR Grimes, P Kannan, A McIntyre, A Kavanagh, A Siddiky, S Wigfield, A Harris, M Partridge, PLoS One - Available here (Open Access) 

 

  • "Estimating oxygen distribution from vasculature in three-dimensional tumour tissue" - DR Grimes, P Kannan, DR Warren, B Markelc, R Bates, R Muschel, M Partridge, journal of the Royal Society Interface - Available here (Open Access). 

  • "Methods: using three-dimensional culture (spheroids) as an in vitro model of tumour hypoxia" - R Leek, DR Grimes, AL Harris, A McIntyre, Tumor Microenvironment - Author proof available here.

  • "On the viability of conspiratorial beliefs" - DR Grimes, PLoS One - Available here (Open Access)

2015

  • "A mechanistic investigation of the oxygen fixation hypothesis and oxygen enhancement ratio" - DR Grimes, M Partridge, Biomedical physics and engineering express - Available here (Open access)

  • "Commentary on “Are fluoride levels in drinking water associated with hypothyroidism prevalence in England? A large observational study of GP practice data and fluoride levels in drinking water”" - DR Grimes, Journal of Epidemiology and Community Health. Author Proof available here. 

  • "Ultraviolet radiation therapy and UVR dose models" - DR Grimes, Medical Physics - Available here (Open Access)

2014

  • "Oxygen consumption dynamics in steady-state tumour models" - DR Grimes, AG Fletcher, M Partridge, Royal Society Open Science -Available here (Open Access) 

  • "String Theory - The Physics of String-Bending and Other Electric Guitar Techniques" - DR Grimes, PLoS One - Available here (Open Access)

  • "A method for estimating the oxygen consumption rate in multicellular tumour spheroids" - DR Grimes, C Kelly, K Bloch, M Partridge, Journal of Royal Society Interface - Available here (Open Access).  

2013

  • "Can you kill your enemy by giving homeopathy? Response by DR Grimes" - DR Grimes, International Journal of Clinical Practice - Author Proof available here, 

2012

  • "A computational simulation of reflector and tube effects in ultraviolet phototherapy" - DR Grimes, Physics in Medicine and Biology. Author Proof available here. 

  • "Proposed mechanisms for homeopathy are physically impossible" - DR Grimes, Focus on Alternative and Complementary Therapies. Author Proof available here. 

  • "Investigations of cabin design in UV phototherapy" - DR Grimes, CJ Martin, G Phanco, Medical Physics - Author Proof available here. 

2011

  • "Reflection modeling in ultraviolet phototherapy" - DR Grimes,  C Robbins, CJ Martin, G Phanco, NJ O'Hare, Medical Physics - Author proof available here. 

  • "Development of a radiation computation dose model for use in ultraviolet phototherapy​" - DR Grimes, Doctoral Thesis, Dublin City University - Available here

2010

  • "Dose modeling in ultraviolet phototherapy" - DR Grimes, C Robbins, NJ O'Hare, Medical Physics - Author Proof available here.